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Image Search Results
Journal: In Vitro Cellular & Developmental Biology. Animal
Article Title: Trisomy 12 compromises the mesendodermal differentiation propensity of human pluripotent stem cells
doi: 10.1007/s11626-023-00824-9
Figure Lengend Snippet: Comparison of global gene expression in trisomy 12 hPSC lines. ( A ) Cluster dendrogram of microarray data from trisomy 12 hPSC lines and their original lines. N = 3 from each lines. ( B–D ) Scatter plot of signal intensity for all microarray probes. Each dot in the plot shows the mean signal intensity of each probe averaged from 3 samples of H9 ( X-axis ) and H9(+ 12) ( Y-axis ) hESC lines ( B ), 201B7 ( X-axis ) and 201B7(+ 12) ( Y-axis ) hiPSC lines ( C ), and 19–9-7 T ( X-axis ) and 19–9-7 T(+ 12) ( Y-axis ) hiPSC lines ( D ). ( E , F ) Pie charts of significantly upregulated ( E ) or downregulated ( F ) probes of the trisomy 12 hPSC lines in common from microarray analysis (FDR < 0.1). ( G , H ) Pie charts of significantly upregulated G or downregulated H probes of the trisomy 12 hPSC lines in common from microarray analysis (FDR < 0.1). The area in blue indicates the ratio of the probes targeting chromosome 12. The area in red indicates the probes targeting the other chromosomes. ( I , J ) The list of “PANTHER” pathways and their p values extracted from the commonly upregulated genes I and downregulated gene J.
Article Snippet:
Techniques: Comparison, Gene Expression, Microarray